Rgs12^tm1Dski
Targeted Allele Detail

Summary

• Symbol: Rgs12^tm1Dski
• Name: regulator of G-protein signaling 12; targeted mutation 1, David Siderovski
• MGI ID: MGI:6389566
• Synonyms: Rgs12^delta5-8, Rgs12^tm1Vse
• Gene: Rgs12 Location: Chr5:35106789-35196988 bp, + strand Genetic Position: Chr5, 17.96 cM
• Alliance: Rgs12^tm1Dski page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260028
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5-8, encoding the entire polypeptide sequence of the RGS domain of RGS12 were targeted for replacement with a lacZ/neomycin cassette. (J:260028)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs12 Mutation: 58 strains or lines available

References

• Original: J:260028 Gross JD, et al., Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants. J Psychopharmacol. 2018 Feb;32(2):191-203
• All: 3 reference(s)