Snai2^tm1.1Wsw
Targeted Allele Detail

Summary

• Symbol: Snai2^tm1.1Wsw
• Name: snail family zinc finger 2; targeted mutation 1.1, Wen-Shu Wu
• MGI ID: MGI:6388786
• Synonyms: Slug^fl
• Gene: Snai2 Location: Chr16:14523716-14527249 bp, + strand Genetic Position: Chr16, 10.07 cM
• Alliance: Snai2^tm1.1Wsw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283540
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert loxp and FRT flanked neo selecttion cassette into intron 2 and another loxP site into intron 3 of the Snai2 gene. FLPE-mediated recombination removed the selection cassette, resulting in exons 2 and 3 flanked by loxP sites. (J:283540)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Snai2 Mutation: 33 strains or lines available

References

• Original: J:283540 Zhu P, et al., The transcription factor Slug represses p16(Ink4a) and regulates murine muscle stem cell aging. Nat Commun. 2019 Jun 12;10(1):2568
• All: 2 reference(s)