Pcid2^tm1.1Imku
Targeted Allele Detail

Summary

• Symbol: Pcid2^tm1.1Imku
• Name: PCI domain containing 2; targeted mutation 1.1, Nobuo Sakaguchi
• MGI ID: MGI:6388554
• Synonyms: Pcid2^-
• Gene: Pcid2 Location: Chr8:13127189-13155459 bp, - strand Genetic Position: Chr8, 5.73 cM
• Alliance: Pcid2^tm1.1Imku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283440
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed neomycin resistance gene was inserted in intron 1 and a third loxP sited was placed in the HindIII site 5' to exon 1. Cre-mediated recombination in the germline resulted in the deletion of the loxP-flanked sequences. (J:283440)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcid2 Mutation: 16 strains or lines available

References

• Original: J:283440 Ye B, et al., Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability. Stem Cells. 2014 Mar;32(3):623-35
• All: 1 reference(s)