Il11^em1Cook
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il11^em1Cook
• Name: interleukin 11; endonuclease-mediated mutation 1, Stuart Cook
• MGI ID: MGI:6388530
• Synonyms: Il11-Luciferase
• Gene: Il11 Location: Chr7:4775372-4785858 bp, - strand Genetic Position: Chr7, 2.76 cM
• Alliance: Il11^em1Cook page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Reporter)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 genome editing is used to introduce Kozak-luciferase-WPRE-polyA sequence into the start codon.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il11 Mutation: 21 strains or lines available

References

• Original: J:320984 Widjaja AA, et al., Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury. Sci Transl Med. 2021 Jun 9;13(597)
• All: 1 reference(s)