Il11^tm1.1Cook
Targeted Allele Detail

Summary

• Symbol: Il11^tm1.1Cook
• Name: interleukin 11; targeted mutation 1.1, Stuart Cook
• MGI ID: MGI:6388528
• Synonyms: Il11-EGFP
• Gene: Il11 Location: Chr7:4775372-4785858 bp, - strand Genetic Position: Chr7, 2.76 cM
• Alliance: Il11^tm1.1Cook page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320984
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A self-excising neomycin cassette was introduced to intron 4 and a viral 2A peptide-EGFP cassette was placed in exon 5, replacing the TGA stop codon. (J:320984)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il11 Mutation: 21 strains or lines available

References

• Original: J:320984 Widjaja AA, et al., Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury. Sci Transl Med. 2021 Jun 9;13(597)
• All: 3 reference(s)