Il11ra1^em1Cook
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il11ra1^em1Cook
• Name: interleukin 11 receptor subunit alpha 1; endonuclease-mediated mutation 1, Stuart Cook
• MGI ID: MGI:6388526
• Synonyms: Il11ra1^loxP
• Gene: Il11ra1 Location: Chr4:41760443-41769473 bp, + strand Genetic Position: Chr4, 21.94 cM
• Alliance: Il11ra1^em1Cook page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• CRISPR/Cas9 genome editing is used to introduce loxP sequences into introns 3 and 7. (J:320984)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il11ra1 Mutation: 35 strains or lines available

References

• Original: J:320984 Widjaja AA, et al., Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury. Sci Transl Med. 2021 Jun 9;13(597)
• All: 4 reference(s)