Tg(tetO-Twist1,-luc)1Dwf
Transgene Detail

Summary

• Symbol: Tg(tetO-Twist1,-luc)1Dwf
• Name: transgene insertion 1, Dean Felsher
• MGI ID: MGI:6387223
• Synonyms: Twist1-tetO7-luc
• Transgene: Tg(tetO-Twist1,-luc)1Dwf Location: unknown
• Alliance: Tg(tetO-Twist1,-luc)1Dwf page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-Twist1,-luc)1Dwf expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Twist1 (MGI:98872)

• Mutation details: The transgenic construct is designed with a bidirectional tetracycline responsive promoter containing the Tet-responsive element (TRE or tetO⁷ seven copies of the 42-bp tet operator sequence [tetO]) directing expression of the mouse Twist1 gene on one side and the luciferase (luc) gene on the other side. (J:185196)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:185196 Tran PT, et al., Twist1 suppresses senescence programs and thereby accelerates and maintains mutant kras-induced lung tumorigenesis. PLoS Genet. 2012 May;8(5):e1002650
• All: 6 reference(s)