Adora2b^tm1Eckl
Targeted Allele Detail

Summary

• Symbol: Adora2b^tm1Eckl
• Name: adenosine A2b receptor; targeted mutation 1, Tobias Eckle
• MGI ID: MGI:6386743
• Synonyms: Adora2b^f
• Gene: Adora2b Location: Chr11:62139810-62157278 bp, + strand Genetic Position: Chr11, 37.96 cM, cytoband B2
• Alliance: Adora2b^tm1Eckl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283234
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 2, and a FRT-PGK-neo-pA-SD-IS-FRT cassette followed by a second loxP site downstream of exon 2. The SD is a splice donor sequence and the IS is a 54bp instability signal. (J:283234)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adora2b Mutation: 19 strains or lines available

References

• Original: J:283234 Seo SW, et al., Differential Tissue-Specific Function of Adora2b in Cardioprotection. J Immunol. 2015 Aug 15;195(4):1732-43
• All: 8 reference(s)