Ostm1^tm1.1Jva
Targeted Allele Detail

Summary

• Symbol: Ostm1^tm1.1Jva
• Name: osteopetrosis associated transmembrane protein 1; targeted mutation 1.1, Jean Vacher
• MGI ID: MGI:6385111
• Synonyms: Ostm1^lox
• Gene: Ostm1 Location: Chr10:42554912-42578458 bp, + strand Genetic Position: Chr10, 22.89 cM
• Alliance: Ostm1^tm1.1Jva page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282819
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence)
• Mutation: Insertion
• Mutation details: A loxP-FRT-PGK-Neo-PGKpA-FRT cassette was introduced to intron 4 and a loxP site was placed in intron 5. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 5 floxed. (J:282819)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ostm1 Mutation: 23 strains or lines available

References

• Original: J:282819 Pata M, et al., Ostm1 Bifunctional Roles in Osteoclast Maturation: Insights From a Mouse Model Mimicking a Human OSTM1 Mutation. J Bone Miner Res. 2018 May;33(5):888-898
• All: 1 reference(s)