Eomes^tm1.1Gtbz
Targeted Allele Detail

Summary

• Symbol: Eomes^tm1.1Gtbz
• Name: eomesodermin; targeted mutation 1.1, Gabrielle T Belz
• MGI ID: MGI:6385033
• Synonyms: Eomes^fl, Eomes^floxed
• Gene: Eomes Location: Chr9:118307259-118315176 bp, + strand Genetic Position: Chr9, 70.21 cM, cytoband F3
• Alliance: Eomes^tm1.1Gtbz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282818
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked IRES-mCherry-neo cassette were inserted in intron 3 via homologous recombination. The original targeting vector had a loxP site in intron 1, but this is not present in this allele. Flp-mediated recombination removed the reporter and selection cassette. (J:282818)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eomes Mutation: 42 strains or lines available

References

• Original: J:282818 Zhang P, et al., Eomesodermin promotes the development of type 1 regulatory T (TR1) cells. Sci Immunol. 2017 Apr 7;2(10)
• All: 1 reference(s)