Ubr5^{Gt(EUCE0171f01)1.1Hmgu}
Gene trapped Allele Detail

Summary

• Symbol: Ubr5^{Gt(EUCE0171f01)1.1Hmgu}
• Name: ubiquitin protein ligase E3 component n-recognin 5; gene trap 1.1, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6384913
• Synonyms: Ubr5WT*
• Gene: Ubr5 Location: Chr15:37967572-38079098 bp, - strand Genetic Position: Chr15, 15.1 cM
• Alliance: Ubr5^{Gt(EUCE0171f01)1.1Hmgu} page

Mutation origin

• Mutant Cell Line: EUCE0171f01
• Germline Transmission: Earliest citation of germline transmission: J:236026
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Conditional ready, No functional change)
• Mutation: Insertion of gene trap vector Vector: rsFlipROSAbgeo*
• Mutation details: A conditional gene trap vector flanked by loxP, lox511 and FRT sites inserted between exons 20 and 21. After flp-mediated recombination, in the non-mutagenic orientation (Ubr5^WT*). Subsequent cre-mediated recombination is required to derive the permanent mutagenic orientation (Ubr5^mt*). (J:236026)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubr5 Mutation: 119 strains or lines available

References

• Original: J:236026 Kinsella E, et al., Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development. PLoS One. 2016;11(6):e0157079
• All: 3 reference(s)