Gt(ROSA)26Sor^{tm1(Neurod1-EGFP)Able}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Neurod1-EGFP)Able}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Andrew B Leiter
• MGI ID: MGI:6384644
• Synonyms: ^LSLNeurod1, Rosa26^{loxp-STOP-loxP}Neurod1-IRES-eGFP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Neurod1-EGFP)Able} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282725
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector was designed with, from 5' to 3', a floxed-STOP cassette containing a neomycin (neo) resistance gene, full-length mouse neurogenic differentiation 1 (Neurod1) cDNA, an internal ribosome entry site (IRES), and an enhanced green fluorescence protein (EGFP). This targeting vector was inserted into the Gt(ROSA)26Sor locus. (J:282725)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:282725 Li HJ, et al., Intestinal Neurod1 expression impairs paneth cell differentiation and promotes enteroendocrine lineage specification. Sci Rep. 2019 Dec 20;9(1):19489
• All: 2 reference(s)