Alk^{tm1.1(ALK*R1275Q)Homy}
Targeted Allele Detail

Summary

• Symbol: Alk^{tm1.1(ALK*R1275Q)Homy}
• Name: anaplastic lymphoma kinase; targeted mutation 1.1, Hiroaki Honda
• MGI ID: MGI:6383960
• Synonyms: ALK(R1275Q), Alk^{tm1(hALK*R1275Q)Homy}
• Gene: Alk Location: Chr17:72175967-72911622 bp, - strand Genetic Position: Chr17, 43.77 cM
• Alliance: Alk^{tm1.1(ALK*R1275Q)Homy} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230720
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A patient-derived human ALK cDNA followed by an IRES-beta geo-polyA selection cassette was fused in-frame to mouse exon 21. The floxed Neomycin resistance gene was deleted by Cre-mediated recombination. (J:230720)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alk Mutation: 66 strains or lines available

References

• Original: J:230720 Ueda T, et al., ALK(R1275Q) perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN. Oncogene. 2016 Aug 25;35(34):4447-58
• All: 1 reference(s)