Rxra^tm1.1Neg
Targeted Allele Detail

Summary

• Symbol: Rxra^tm1.1Neg
• Name: retinoid X receptor alpha; targeted mutation 1.1, Masahiko Negishi
• MGI ID: MGI:6383951
• Synonyms: Rxra^T167A
• Gene: Rxra Location: Chr2:27566452-27652969 bp, + strand Genetic Position: Chr2, 19.38 cM
• Alliance: Rxra^tm1.1Neg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282714
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector containing an ACN self-excising loxP-flanked neomycin cassette and a diptheria toxin (DTA) gene was used to replace the threonine residue at position 167 with an alanine residue. The left homology arm included all of exons 2, 3, and 4 (including the T167A substitution codon in exon 4), while the right homology arm contained part of intron 4. (J:282714)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rxra Mutation: 30 strains or lines available

References

• Original: J:282714 Sueyoshi T, et al., A phosphorylation-deficient mutant of retinoid X receptor alpha at Thr 167 alters fasting response and energy metabolism in mice. Lab Invest. 2019 Oct;99(10):1470-1483
• All: 1 reference(s)