Il15^tm1.2Nsl
Targeted Allele Detail

Summary

• Symbol: Il15^tm1.2Nsl
• Name: interleukin 15; targeted mutation 1.2, Nan-Shih Liao
• MGI ID: MGI:6382897
• Gene: Il15 Location: Chr8:83058261-83129851 bp, - strand Genetic Position: Chr8, 39.33 cM
• Alliance: Il15^tm1.2Nsl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: V26.2 (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 3 and an FRT-flanked neomycin selection cassette, followed by a second loxP site, downstream of exon 5. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 3 through 5 floxed. Cre-mediated recombination removed exons 3-5. (J:279981)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il15 Mutation: 42 strains or lines available

References

• Original: J:279981 Liou YH, et al., Adipocyte IL-15 regulates local and systemic NK cell development. J Immunol. 2014 Aug 15;193(4):1747-58
• All: 6 reference(s)