Mc3r^{tm2.1(MC3R*)Jayk}
Targeted Allele Detail

Summary

• Symbol: Mc3r^{tm2.1(MC3R*)Jayk}
• Name: melanocortin 3 receptor; targeted mutation 2.1, Jack A Yanovski
• MGI ID: MGI:6382576
• Synonyms: MC3R^hDM
• Gene: Mc3r Location: Chr2:172090412-172093034 bp, + strand Genetic Position: Chr2, 94.8 cM
• Alliance: Mc3r^{tm2.1(MC3R*)Jayk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236064
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Mc3r^{tm2.1(MC3R*)Jayk} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MC3R (4159)

  Mc3r	(MGI:96929)

  Double mutant variant (C17A and G241A)

• Mutation details: The mouse coding region was replaced with the double mutation (C17A and G241A) human variant sequence, a TAG epitope and floxed neomycin resistace cassette. Cre-mediated recombination removed the selection cassette. (J:236064)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mc3r Mutation: 30 strains or lines available

References

• Original: J:236064 Lee B, et al., A mouse model for a partially inactive obesity-associated human MC3R variant. Nat Commun. 2016 Jan 28;7:10522
• All: 2 reference(s)