Slc6a5tm1.1(cre)Ksak
Targeted Allele Detail
|
Symbol: |
Slc6a5tm1.1(cre)Ksak |
Name: |
solute carrier family 6 (neurotransmitter transporter, glycine), member 5; targeted mutation 1.1, Kenji Sakimura |
MGI ID: |
MGI:6382286 |
Synonyms: |
GLYT2Cre, Slc6a5tm1.1(cre)Yyan |
Gene: |
Slc6a5 Location: Chr7:49559894-49613604 bp, + strand Genetic Position: Chr7, 31.71 cM, cytoband B3
|
Alliance: |
Slc6a5tm1.1(cre)Ksak page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:279620
|
Parent Cell Line: |
RENKA (ES Cell)
|
Strain of Origin: |
C57BL/6N
|
|
Allele Type: |
|
Targeted (Recombinase) |
Mutation: |
|
Insertion
|
|
|
Slc6a5tm1.1(cre)Ksak expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Slc6a5 (MGI:105090) |
|
|
|
|
Mutation details: A Cre cDNA, a polyadenylation signal (pA) from the human granulocyte-colony stimulating factor gene, a phosphoglycerate kinase (PGK) promoter-driven neomycin resistance gene (neo)-pA cassette (PGK-neo-pA cassette) flanked by two frt sites were inserted into the translation initiation
site (in exon 2) of the mouse Slc6a5 gene by homologous recombination in ES cells. The PGK-neo-pA cassette was removed by crossing mice with FLP66 transgenic mice.
(J:279620)
|
|
|
Activity: |
Tissue activity of this recombinase allele
|
Driver:
|
Slc6a5
(mouse)
|
|
|
|
|
Original: |
J:279620 Kakizaki T, et al., A glycine transporter 2-Cre knock-in mouse line for glycinergic neuron-specific gene manipulation. IBRO Rep. 2017 Dec;3:9-16 |
All: |
3 reference(s) |
|