Gabra2C57BL/6J+em1Geh
Endonuclease-mediated Allele Detail
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Symbol: |
Gabra2C57BL/6J+em1Geh |
Name: |
gamma-aminobutyric acid type A receptor subunit alpha 2; endonuclease-mediated revertant 1, Gregg E Homanics |
MGI ID: |
MGI:6381661 |
Synonyms: |
Gabra2em1Geh, Gabra2KI, Rr126C57BL/6J+em1Geh |
Gene: |
Gabra2 Location: Chr5:71115735-71253192 bp, - strand Genetic Position: Chr5, 37.59 cM
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Alliance: |
Gabra2C57BL/6J+em1Geh page
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Allele Type: |
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Endonuclease-mediated (Modified regulatory region) |
Mutations: |
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Insertion, Single point mutation
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Mutation details: CRISPR/Cas9 was used to insert a single base pair (A on negative strand) between Chr5:71,014,638-639 to correct the spontaneous deletion of an A in intron 4 that is inherent in C57BL/6J and BXD40. This restores the allele to the "wild-type" form as found in C57BL/6NJ, C57BL/6ByJ, C57BL/6EiJ, DBA/2J and others.
(J:280223)
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Inheritance: |
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Dominant |
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Original: |
J:280223 Mulligan MK, et al., Identification of a Functional Non-coding Variant in the GABA A Receptor alpha2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research. Front Genet. 2019;10:188 |
All: |
3 reference(s) |
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