Sting1^tm2.1Camb
Targeted Allele Detail

Summary

• Symbol: Sting1^tm2.1Camb
• Name: stimulator of interferon response cGAMP interactor 1; targeted mutation 2.1, John Cambier
• MGI ID: MGI:6379576
• Synonyms: STING-HAQ
• Gene: Sting1 Location: Chr18:35866732-35873607 bp, - strand Genetic Position: Chr18, 19.23 cM, cytoband B3
• Alliance: Sting1^tm2.1Camb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247744
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting vector was designed to insert an FRT-flanked neomycin resistance (neo) cassette downstream of exon 5 of the gene. Three common alternative allelic variants (R71H-I229A-R292Q) equivalent to those found in humans (R71H-G230A-R293Q) were introduced as follows - exon 3 was modified to harbor R71H, exon 6 modified to harbor G230A, and exon 7a was modified to harbor R293Q. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:247744)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sting1 Mutation: 45 strains or lines available

References

• Original: J:247744 Patel S, et al., The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele. J Immunol. 2017 Jan 15;198(2):776-787
• All: 3 reference(s)