Rest^tm1.2Bban
Targeted Allele Detail

Summary

• Symbol: Rest^tm1.2Bban
• Name: RE1-silencing transcription factor; targeted mutation 1.2, Botond Banfi
• MGI ID: MGI:6378686
• Synonyms: Rest^deltaEx4
• Gene: Rest Location: Chr5:77413338-77434279 bp, + strand Genetic Position: Chr5, 41.61 cM
• Alliance: Rest^tm1.2Bban page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265659
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and a frt-flanked neomycin resistance gene were inserted upstream of exon 4 and a second loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and cre-mediated recombination deleted exon 4. Deletion of exon 4 prevents the production of the exon4-containing splice form without reducing expression of the form lacking this exon. (J:265659)

Expression

In Mice Carrying this Mutation:	1 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rest Mutation: 95 strains or lines available

References

• Original: J:265659 Nakano Y, et al., Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness. Cell. 2018 Jul 26;174(3):536-548.e21
• All: 2 reference(s)