Bdnf^tm1.1Bail
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm1.1Bail
• Name: brain derived neurotrophic factor; targeted mutation 1.1, Bai Liu
• MGI ID: MGI:6378539
• Synonyms: Bdnf-e4^-
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm1.1Bail page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269842
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An enhanced green fluorescent protein (EGFP)-STOP cassette, followed by a loxP-flanked neomycin selection cassette (neo) in reverse orientation was inserted 3' of the promoter IV exon. Cre-mediated recombination removed the upstream floxed neo cassette. (J:269842)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:147571 Sakata K, et al., Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5942-7
• All: 3 reference(s)