About   Help   FAQ
Pdgfratm1.1(cre/ERT2)Trdo
Targeted Allele Detail
Summary
Symbol: Pdgfratm1.1(cre/ERT2)Trdo
Name: platelet derived growth factor receptor, alpha polypeptide; targeted mutation 1.1, Thomas A Rando
MGI ID: MGI:6377446
Synonyms: PDGFRalphaCreER
Gene: Pdgfra  Location: Chr5:75312953-75358876 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance: Pdgfratm1.1(cre/ERT2)Trdo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:280557
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Pdgfratm1.1(cre/ERT2)Trdo expression driven by 1 gene
 
Mutation detailsA targeting vector was designed to place a FRT-flanked neo cassete in intron 3 and CreERT2 minigene inserted after ATG start codon in exon 4 of the mouse PDGFRa locus. The neo marker was subsequently removed by crossing Flp deleter mouse. (J:280557)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pdgfra (mouse)
Summary of all recombinase alleles driven by Pdgfra.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdgfra Mutation:  85 strains or lines available
References
Original:  J:280557 Wosczyna MN, et al., Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle. Cell Rep. 2019 May 14;27(7):2029-2035.e5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/21/2024
MGI 6.23
The Jackson Laboratory