Tg(HBA-CD59*H44Q)1Jha
Transgene Detail

Summary

• Symbol: Tg(HBA-CD59*H44Q)1Jha
• Name: transgene insertion 1, Jose A Halperin
• MGI ID: MGI:6376204
• Synonyms: hCD59H44Q
• Transgene: Tg(HBA-CD59*H44Q)1Jha Location: unknown
• Alliance: Tg(HBA-CD59*H44Q)1Jha page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(HBA-CD59*H44Q)1Jha expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD59 (966)

  Cd59a	(MGI:109177)
  Cd59b	(MGI:1888996)

  contains a H44Q amino acid substitution

• Mutation details: The ~7 kb transgene is designed with the human locus control region (LCR) and the alpha globin (HBA) gene promoter driving expression of mutant human CD59 antigen (CD59) cDNA. hCD59 was modified to harbor a histidine to glutamine substitution at amino acid 44 (H44Q). (J:280723)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:280723 Sahoo R, et al., A distinctive histidine residue is essential for in vivo glycation-inactivation of human CD59 transgenically expressed in mice erythrocytes: Implications for human diabetes complications. Am J Hematol. 2017 Nov;92(11):1198-1203
• All: 1 reference(s)