Spn^tm1Jcln
Targeted Allele Detail

Summary

• Symbol: Spn^tm1Jcln
• Name: sialophorin; targeted mutation 1, Judy L Cannon
• MGI ID: MGI:6376116
• Synonyms: CD43^NGG
• Gene: Spn Location: Chr7:126731404-126736995 bp, - strand Genetic Position: Chr7, 69.35 cM, cytoband F3-F4
• Alliance: Spn^tm1Jcln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279839
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: The tripeptide sequence KRR required for binding to ezrin-radixin-moiesin cytoskeletal proteins was altered to NGG. (J:279839)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spn Mutation: 26 strains or lines available

References

• Original: J:279839 Alisson-Silva F, et al., CD43 sialoglycoprotein modulates cardiac inflammation and murine susceptibility to Trypanosoma cruzi infection. Sci Rep. 2019 Jun 13;9(1):8628
• All: 1 reference(s)