Sirt3^em1Jkch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sirt3^em1Jkch
• Name: sirtuin 3; endonuclease-mediated mutation 1, Jinke Cheng
• MGI ID: MGI:6370174
• Synonyms: Sirt3^K223R
• Gene: Sirt3 Location: Chr7:140443579-140462222 bp, - strand Genetic Position: Chr7, 86.07 cM, cytoband F4
• Alliance: Sirt3^em1Jkch page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting produced an A to G point mutation that results in the amino acid substitution of arginine for lysine at position 223 (K223R). (J:279872)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt3 Mutation: 32 strains or lines available

References

• Original: J:279872 Wang T, et al., SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism. Mol Cell. 2019 Aug 22;75(4):823-834.e5
• All: 3 reference(s)