Dcaf6^tm1.1Ntuy
Targeted Allele Detail

Summary

• Symbol: Dcaf6^tm1.1Ntuy
• Name: DDB1 and CUL4 associated factor 6; targeted mutation 1.1, National Taiwan University
• MGI ID: MGI:6368839
• Synonyms: NRIP-knockout
• Gene: Dcaf6 Location: Chr1:165157069-165288475 bp, - strand Genetic Position: Chr1, 72.67 cM, cytoband H2
• Alliance: Dcaf6^tm1.1Ntuy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233771
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the selection cassette and exon 2. Western blot analysis confirmed the absence of protein expression in muscles. (J:233771)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dcaf6 Mutation: 41 strains or lines available

References

• Original: J:233771 Chen HH, et al., NRIP is newly identified as a Z-disc protein, activating calmodulin signaling for skeletal muscle contraction and regeneration. J Cell Sci. 2015 Nov 15;128(22):4196-209
• All: 1 reference(s)