Rbbp8^Sum6-Jus
Chemically induced Allele Detail

Summary

• Symbol: Rbbp8^Sum6-Jus
• Name: retinoblastoma binding protein 8, endonuclease; suppressor of methyl CpG binding protein 2-6, 1 Monica J Justice
• MGI ID: MGI:6367664
• Synonyms: Line 895
• Gene: Rbbp8 Location: Chr18:11766333-11876264 bp, + strand Genetic Position: Chr18, 5.85 cM
• Alliance: Rbbp8^Sum6-Jus page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Translocation
• Mutation details:

  This allele was discovered in a screen for attenuation of the Mecp2^tm1.1Bird/Y phenotype among male G1 offspring from crosses of 129S-Mecp2^tm1.1Bird/+ female mice by ENU-treated C57BL/6J males (G0). The mutation has been identified as a C to T resulting in the amino acid substitution of a stop codon for glutamine at position 743 (exon15:c.2227C>T:p.Q743X (895)). (J:323637)

• Inheritance: Other (see notes)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbbp8 Mutation: 51 strains or lines available

Notes

Dominant modifier

References

• Original: J:323637 Enikanolaiye A, et al., Suppressor mutations in Mecp2-null mice implicate the DNA damage response in Rett syndrome pathology. Genome Res. 2020 Apr;30(4):540-552
• All: 1 reference(s)