Hvcn1^tm1.1Ksak
Targeted Allele Detail

Summary

• Symbol: Hvcn1^tm1.1Ksak
• Name: hydrogen voltage-gated channel 1; targeted mutation 1.1, Kenji Sakimura
• MGI ID: MGI:6363974
• Synonyms: Hvcn1^-
• Gene: Hvcn1 Location: Chr5:122344872-122380360 bp, + strand Genetic Position: Chr5, 62.23 cM
• Alliance: Hvcn1^tm1.1Ksak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245117
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exon 5 was deleted following Cre-mediated recombination of flanking loxP sites. (J:245117)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hvcn1 Mutation: 32 strains or lines available

References

• Original: J:245117 Kawai T, et al., Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production. J Neurochem. 2017 Sep;142(5):686-699
• All: 4 reference(s)