Mysm1^em1Nki
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mysm1^em1Nki
• Name: myb-like, SWIRM and MPN domains 1; endonuclease-mediated mutation 1, The Netherlands Cancer Institute
• MGI ID: MGI:6363967
• Synonyms: MYSM1^D660N, Mysm1D660N, Mysm1^DN
• Gene: Mysm1 Location: Chr4:94830277-94867337 bp, - strand Genetic Position: Chr4, 43.34 cM
• Alliance: Mysm1^em1Nki page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting using gRNA(5'-GTGTCAATATCTCGTAAAGA TGG-3') generated a point mutation in exon 16 - D660N (GAT to AAT) and a silent mutation in R659 (CGA to AGG). (J:332556)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mysm1 Mutation: 44 strains or lines available

References

• Original: J:332556 Liang Y, et al., Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development. Sci Rep. 2023 Jan 7;13(1):338
• All: 2 reference(s)