Cacna1g^tm1.1Ksak
Targeted Allele Detail

Summary

• Symbol: Cacna1g^tm1.1Ksak
• Name: calcium channel, voltage-dependent, T type, alpha 1G subunit; targeted mutation 1.1, Kenji Sakimura
• MGI ID: MGI:6363719
• Synonyms: Cacna1g^flox/+ -neo/+
• Gene: Cacna1g Location: Chr11:94299217-94365024 bp, - strand Genetic Position: Chr11, 58.9 cM
• Alliance: Cacna1g^tm1.1Ksak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151612
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5 and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. The neomycin selection cassette was removed via Flp-mediated recombination. (J:151612)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cacna1g Mutation: 104 strains or lines available

References

• Original: J:151612 Petrenko AB, et al., Mutation of alpha1G T-type calcium channels in mice does not change anesthetic requirements for loss of the righting reflex and minimum alveolar concentration but delays the onset of anesthetic induction. Anesthesiology. 2007 Jun;106(6):1177-85
• All: 1 reference(s)