Erbb4^tm2Line
Targeted Allele Detail

Summary

• Symbol: Erbb4^tm2Line
• Name: erb-b2 receptor tyrosine kinase 4; targeted mutation 2, Lin Mei
• MGI ID: MGI:6363568
• Synonyms: Stop-ErbB4
• Gene: Erbb4 Location: Chr1:68071345-69147218 bp, - strand Genetic Position: Chr1, 33.8 cM
• Alliance: Erbb4^tm2Line page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269263
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a loxP-NeotpA-loxP cassette into the 1st intron (between exons 1 and 2) of the gene resulted in a null allele; restoration of gene expression is observed upon recombination of the loxP sites. (J:269263)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb4 Mutation: 87 strains or lines available

References

• Original: J:269263 Wang H, et al., Genetic recovery of ErbB4 in adulthood partially restores brain functions in null mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13105-13110
• All: 2 reference(s)