Ifnar1^em1Smli
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ifnar1^em1Smli
• Name: interferon (alpha and beta) receptor 1; endonuclease-mediated mutation 1, Scott M Lieberman
• MGI ID: MGI:6363564
• Synonyms: Ifnar1^em16
• Gene: Ifnar1 Location: Chr16:91282126-91304329 bp, + strand Genetic Position: Chr16, 52.98 cM
• Alliance: Ifnar1^em1Smli page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1 was targeted with sgRNA 5'-GCTCGCTGTCGTGGGCGCGG-3' using CRISPR/Cas9 technology. Mutant em16 has a 5bp deletion, causing a frameshift and premature stop codon. (J:279105)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifnar1 Mutation: 62 strains or lines available

References

• Original: J:279105 Chaly Y, et al., Type I Interferon Signaling Is Required for Dacryoadenitis in the Nonobese Diabetic Mouse Model of Sjogren Syndrome. Int J Mol Sci. 2018 Oct 20;19(10):3259
• All: 3 reference(s)