Nlrc3^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nlrc3^em1Smoc
• Name: NLR family, CARD domain containing 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6363215
• Gene: Nlrc3 Location: Chr16:3762871-3794496 bp, - strand Genetic Position: Chr16, 2.32 cM
• Alliance: Nlrc3^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 genome editing technology was used to create a deletion of exons 2-6 of the gene. (J:278921)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nlrc3 Mutation: 53 strains or lines available

References

• Original: J:278921 Fu Y, et al., NLRC3 expression in dendritic cells attenuates CD4(+) T cell response and autoimmunity. EMBO J. 2019 Aug 15;38(16):e101397
• All: 1 reference(s)