Tff1^em1Hwl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tff1^em1Hwl
• Name: trefoil factor 1; endonuclease-mediated mutation 1, Han-Woong Lee
• MGI ID: MGI:6363056
• Gene: Tff1 Location: Chr17:31380369-31384034 bp, - strand Genetic Position: Chr17, 15.8 cM
• Alliance: Tff1^em1Hwl page

Mutation origin

• Strain of Origin: C57BL/6JBomTac

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to create a deletion of 856 base pairs encompassing exon 1. (J:278834)

Tumor Data

List all tumor models in MMHCdb carrying Tff1^em1Hwl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tff1 Mutation: 17 strains or lines available

References

• Original: J:278834 Kim H, et al., Disruption of the Tff1 gene in mice using CRISPR/Cas9 promotes body weight reduction and gastric tumorigenesis. Lab Anim Res. 2018 Dec;34(4):257-263
• All: 1 reference(s)