Nrg1^{em2(cre/ERT2)Bzsh}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nrg1^{em2(cre/ERT2)Bzsh}
• Name: neuregulin 1; endonuclease-mediated mutation 2, Bin Zhou
• MGI ID: MGI:6361465
• Synonyms: Nrg1-CrexER
• Gene: Nrg1 Location: Chr8:32299493-33381858 bp, - strand Genetic Position: Chr8, 18.75 cM
• Alliance: Nrg1^{em2(cre/ERT2)Bzsh} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Nrg1^{em2(cre/ERT2)Bzsh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nrg1 (MGI:96083)

• Mutation details: The mouse line was generated by homologous recombination using the CRISPR/Cas9 technology. A complementary DNA encoding Cre recombinase fused with 2 rox sequences flanking a mutant form of the ESR hormone-binding domain (ERT2) was inserted into the translational start codon ATG of the Nrg1 gene and followed by a polyadenylation sequences. (J:278094)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nrg1 (mouse) Summary of all recombinase alleles driven by Nrg1. Comparative matrix view of recombinase activities Alliance mouse Nrg1 gene page

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrg1 Mutation: 53 strains or lines available

References

• Original: J:278094 Pu W, et al., Genetic Targeting of Organ-Specific Blood Vessels. Circ Res. 2018 Jun 22;123(1):86-99
• All: 1 reference(s)