Apex1^tm1.1Pmc
Targeted Allele Detail

Summary

• Symbol: Apex1^tm1.1Pmc
• Name: apurinic/apyrimidinic endonuclease 1; targeted mutation 1.1, Peter J McKinnon
• MGI ID: MGI:6361426
• Synonyms: Ape1^loxP
• Gene: Apex1 Location: Chr14:51162425-51164596 bp, + strand Genetic Position: Chr14, 26.3 cM, cytoband C3
• Alliance: Apex1^tm1.1Pmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269212
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector contains an FRT-flanked neomycin selection cassette and a loxP site inserted in intron 1 and a second loxP site inserted downstream of exon 3. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 2 through 3 floxed. (J:269212)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apex1 Mutation: 14 strains or lines available

References

• Original: J:269212 Dumitrache LC, et al., Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12285-E12294
• All: 2 reference(s)