Stat1^{tm1d(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Stat1^{tm1d(EUCOMM)Wtsi}
• Name: signal transducer and activator of transcription 1; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:6360713
• Synonyms: Stat1^{tm1d(EUCOMM)Ciphe)}
• Gene: Stat1 Location: Chr1:52158599-52201024 bp, + strand Genetic Position: Chr1, 26.81 cM
• Alliance: Stat1^{tm1d(EUCOMM)Wtsi} page
• IMPC: Stat1 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267220
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: First Flp- and then Cre-mediated excision of the parental Stat1^{tm1a(EUCOMM)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette, the IRES-BetaGal reporter expression cassette and critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:267220)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat1 Mutation: 73 strains or lines available

References

• Original: J:267220 Tomasello E, et al., Molecular dissection of plasmacytoid dendritic cell activation in vivo during a viral infection. EMBO J. 2018 Oct 1;37(19)
• All: 1 reference(s)