Odad3^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Odad3^{tm1c(EUCOMM)Hmgu}
• Name: outer dynein arm docking complex subunit 3; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6360701
• Synonyms: Ccdc151^Con
• Gene: Odad3 Location: Chr9:21901167-21913930 bp, - strand Genetic Position: Chr9, 8.01 cM, cytoband A4
• Alliance: Odad3^{tm1c(EUCOMM)Hmgu} page
• IMPC: Odad3 gene page

Mutation origin

• Mutant Cell Line: HEPD0634_2_D03
• Germline Transmission: Earliest citation of germline transmission: J:278798
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 21908891 of Chromosome 9 upstream of the critical exons 2 and 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 21909920. The critical exons 2 and 3 thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:278798)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Odad3 Mutation: 27 strains or lines available

References

• Original: J:278798 Chiani F, et al., Functional loss of Ccdc1 51 leads to hydrocephalus in a mouse model of primary ciliary dyskinesia. Dis Model Mech. 2019 Aug 2;12(8):dmm038489
• All: 1 reference(s)