Dennd1a^em1Jgfu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dennd1a^em1Jgfu
• Name: DENN domain containing 1A; endonuclease-mediated mutation 1, Jiang Fu
• MGI ID: MGI:6360168
• Gene: Dennd1a Location: Chr2:37689003-38177402 bp, - strand Genetic Position: Chr2, 24.19 cM
• Alliance: Dennd1a^em1Jgfu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN-targeting of exon 2 deleted 2 bp (c.60_61delTT, 3rd base of codon 20 and 1st base of codon 21), leading to a reading frame shift and premature termination. (J:276703)

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dennd1a Mutation: 59 strains or lines available

References

• Original: J:276703 Shi J, et al., Dennd1a, a susceptibility gene for polycystic ovary syndrome, is essential for mouse embryogenesis. Dev Dyn. 2019 May;248(5):351-362
• All: 1 reference(s)