Pnoc^{tm1.1(cre)Mrbr}
Targeted Allele Detail

Summary

• Symbol: Pnoc^{tm1.1(cre)Mrbr}
• Name: prepronociceptin; targeted mutation 1.1, Michael R Bruchas
• MGI ID: MGI:6359738
• Synonyms: Pnoc-IRES-Cre
• Gene: Pnoc Location: Chr14:65638122-65662921 bp, - strand Genetic Position: Chr14, 34.33 cM, cytoband D1
• Alliance: Pnoc^{tm1.1(cre)Mrbr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278343
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Pnoc^{tm1.1(cre)Mrbr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pnoc (MGI:105308)

• Mutation details: Cre recombinase gene preceded by an internal ribosomal entry sequence (IRES-Cre) was inserted downstream of the mouse Pnoc stop codon. Following germline transmission, mice were crossed to Rosa-FLPR mice to remove the neo cassette at the 3' end of the IRES-cre sequence. (J:278343)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pnoc (mouse) Summary of all recombinase alleles driven by Pnoc. Comparative matrix view of recombinase activities Alliance mouse Pnoc gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pnoc Mutation: 12 strains or lines available

References

• Original: J:278343 Parker KE, et al., A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward. Cell. 2019 Jul 25;178(3):653-671.e19
• All: 4 reference(s)