Cdh2^tm2Linli
Targeted Allele Detail

Summary

• Symbol: Cdh2^tm2Linli
• Name: cadherin 2; targeted mutation 1, Linheng Li
• MGI ID: MGI:6359730
• Synonyms: N-cad-TdT
• Gene: Cdh2 Location: Chr18:16721934-16942303 bp, - strand Genetic Position: Chr18, 10.1 cM
• Alliance: Cdh2^tm2Linli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278627
• Parent Cell Line: GermLine mESC C57BL6/129SvJ, ASE-9005 (ES Cell)
• Strain of Origin: (C57BL/6 x 129X1/SvJ)F1

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details:

  The targeting vector containing T2A-tdTomato-P2A-CreERT-FRT-kan/neoR-FRT is inserted into exon 16 of the gene, replacing the endogenous stop codon. Cre expression is not detected when combined with Cre reporter strains. (J:278627)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh2 Mutation: 51 strains or lines available

References

• Original: J:278627 Zhao M, et al., N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells. Cell Rep. 2019 Jan 15;26(3):652-669.e6
• All: 1 reference(s)