Hcrtr1^tm1.2Iiis
Targeted Allele Detail

Summary

• Symbol: Hcrtr1^tm1.2Iiis
• Name: hypocretin (orexin) receptor 1; targeted mutation 1.2, Masashi Yanagisawa and Hiromasa Funato
• MGI ID: MGI:6359713
• Gene: Hcrtr1 Location: Chr4:130024010-130033152 bp, - strand Genetic Position: Chr4, 63.43 cM
• Alliance: Hcrtr1^tm1.2Iiis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278619
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5 and 6 are flanked by loxP sequences. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. Cre-mediated recombinase removed exons 5 and 6 resulting in a premature stop codon. (J:278619)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcrtr1 Mutation: 33 strains or lines available

References

• Original: J:278619 Kakizaki M, et al., Differential roles of each orexin receptor signaling in obesity. iScience. 2019
• All: 2 reference(s)