Hnrnph1^em1Lagbu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hnrnph1^em1Lagbu
• Name: heterogeneous nuclear ribonucleoprotein H1; endonuclease-mediated mutation 1, Camron Bryant
• MGI ID: MGI:6358741
• Synonyms: Hnrnph1^-
• Gene: Hnrnph1 Location: Chr11:50267817-50277355 bp, + strand Genetic Position: Chr11, 30.56 cM, cytoband B1.2
• Alliance: Hnrnph1^em1Lagbu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Left TAL effector (50,191,867-50,191,883 bp) and right TAL effector (50,191,899-50,191,915 bp) separated by the FokI cleavage zone was used to introduce a 16 bp frameshift deletion in the first coding exon (exon 4). The mutation results in a premature stop codon. Founder 28 was established. qPCR analysis demonstrated a significant downregulation of transcript levels in heterozygous mutant mice. (J:232145)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hnrnph1 Mutation: 26 strains or lines available

References

• Original: J:232145 Yazdani N, et al., Hnrnph1 Is A Quantitative Trait Gene for Methamphetamine Sensitivity. PLoS Genet. 2015 Dec;11(12):e1005713
• All: 5 reference(s)