Padi2^em1Kkas
Endonuclease-mediated Allele Detail

Summary

• Symbol: Padi2^em1Kkas
• Name: peptidyl arginine deiminase, type II; endonuclease-mediated mutation 1, Kenichi Kashimada
• MGI ID: MGI:6358576
• Synonyms: Padi2^-
• Gene: Padi2 Location: Chr4:140633655-140679897 bp, + strand Genetic Position: Chr4, 73.01 cM, cytoband E1
• Alliance: Padi2^em1Kkas page

Mutation origin

• Strain of Origin: B6D2F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: Cas9 mRNA and single-guide RNA (sgRNA) targeting exon 1 of mouse Padi2 was microinjected into the cytoplasm of zygote-stage embryos to induce deletions. The line that carried a frameshift mutation was selected. (J:278064)

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Padi2 Mutation: 45 strains or lines available

References

• Original: J:278064 Tsuji-Hosokawa A, et al., Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development. Sci Rep. 2018 Sep 5;8(1):13263
• All: 1 reference(s)