Ndufs2^tm1.1Job
Targeted Allele Detail

Summary

• Symbol: Ndufs2^tm1.1Job
• Name: NADH:ubiquinone oxidoreductase core subunit S2; targeted mutation 1, Jose Lopez-Barneo
• MGI ID: MGI:6358287
• Synonyms: Ndufs2^F
• Gene: Ndufs2 Location: Chr1:171062426-171078956 bp, - strand Genetic Position: Chr1, 79.25 cM
• Alliance: Ndufs2^tm1.1Job page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266510
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a FRT flanked neomycin cassette with a 3' loxP site was inserted downstream of exon 2. The neo cassette was removed to produce the final conditional allele. (J:266510)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ndufs2 Mutation: 33 strains or lines available

References

• Original: J:266510 Fernandez-Aguera MC, et al., Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling. Cell Metab. 2015 Nov 3;22(5):825-37
• All: 8 reference(s)