Tmem176b^tm1Ics
Targeted Allele Detail

Summary

• Symbol: Tmem176b^tm1Ics
• Name: transmembrane protein 176B; targeted mutation 1, Mouse Clinical Institute
• MGI ID: MGI:6358050
• Gene: Tmem176b Location: Chr6:48810745-48818363 bp, - strand Genetic Position: Chr6, 23.75 cM
• Alliance: Tmem176b^tm1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263140
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 1 and 2 were replaced with a loxP-flanked neomycin selection cassette. (J:263140)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem176b Mutation: 22 strains or lines available

References

• Original: J:263140 Segovia M, et al., Autologous dendritic cells prolong allograft survival through Tmem176b-dependent antigen cross-presentation. Am J Transplant. 2014 May;14(5):1021-1031
• All: 3 reference(s)