Kat5^tm2Tfaz
Targeted Allele Detail

Summary

• Symbol: Kat5^tm2Tfaz
• Name: K(lysine) acetyltransferase 5; targeted mutation 2, Thomas Fazzio
• MGI ID: MGI:6357985
• Synonyms: Tip55^-
• Gene: Kat5 Location: Chr19:5653042-5660265 bp, - strand Genetic Position: Chr19, 4.34 cM
• Alliance: Kat5^tm2Tfaz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278470
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Specific knockout of the Tip55 isoform of Kat5 by targeting a construct to the Kat5 locus that fuses the last four exons and removes the intervening introns, one of which is retained in the Tip55 transcript. The resulting mouse expresses all other Kat5 isoforms normally but not Tip55. (J:278470)

Expression

In Mice Carrying this Mutation:

16 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kat5 Mutation: 25 strains or lines available

References

• Original: J:278470 Acharya D, et al., TIP55, a splice isoform of the KAT5 acetyltransferase, is essential for developmental gene regulation and organogenesis. Sci Rep. 2018 Oct 8;8(1):14908
• All: 1 reference(s)