Usp19^em1Hbsh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Usp19^em1Hbsh
• Name: ubiquitin specific peptidase 19; endonuclease-mediated mutation 1, Hong-Bing Shu
• MGI ID: MGI:6357908
• Gene: Usp19 Location: Chr9:108367806-108379536 bp, + strand Genetic Position: Chr9, 59.42 cM
• Alliance: Usp19^em1Hbsh page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Single point mutation
• Mutation details: CRISPR/Cas9 mediated recombination inserted a T into exon 3 resulting a frameshift and early translation termination at 42 amino acids. Immunoblot analysis confirmed the absence of protein expression in homozygous cells. (J:276968)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp19 Mutation: 63 strains or lines available

References

• Original: J:276968 Lei CQ, et al., USP19 Inhibits TNF-alpha- and IL-1beta-Triggered NF-kappaB Activation by Deubiquitinating TAK1. J Immunol. 2019 Jul 1;203(1):259-268
• All: 2 reference(s)