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Klrg1tm1.1(EGFP/icre)Flv
Targeted Allele Detail
Summary
Symbol: Klrg1tm1.1(EGFP/icre)Flv
Name: killer cell lectin-like receptor subfamily G, member 1; targeted mutation 1.1, Richard A Flavell
MGI ID: MGI:6357845
Synonyms: Klrg1Cre
Gene: Klrg1  Location: Chr6:122247555-122259792 bp, - strand  Genetic Position: Chr6, 57.52 cM
Alliance: Klrg1tm1.1(EGFP/icre)Flv page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:272661
Parent Cell Line:  JM8A1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Mutation
description
Allele Type:    Targeted (Recombinase, Reporter)
Mutation:    Insertion
 
Klrg1tm1.1(EGFP/icre)Flv expression driven by 1 gene
 
Mutation detailsThe targeting construct containing a Frt-flanked Neomycin resistance gene (Neo), a thymidine kinase, and a fragment encoding an IRES-eGFP-iCre fusion protein was used for homologous recombination in ES cells to insert the reporter cassette immediately after the stop codon of the Klrg1 gene. Germline transmitted mice were bred with FLPo mice to remove the neo gene. (J:272661)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Klrg1 (mouse)
Summary of all recombinase alleles driven by Klrg1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klrg1 Mutation:  22 strains or lines available
References
Original:  J:272661 Herndler-Brandstetter D, et al., KLRG1(+) Effector CD8(+) T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. Immunity. 2018 Apr 17;48(4):716-729.e8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory