Klrg1tm1.1(EGFP/icre)Flv
Targeted Allele Detail
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Symbol: |
Klrg1tm1.1(EGFP/icre)Flv |
Name: |
killer cell lectin-like receptor subfamily G, member 1; targeted mutation 1.1, Richard A Flavell |
MGI ID: |
MGI:6357845 |
Synonyms: |
Klrg1Cre |
Gene: |
Klrg1 Location: Chr6:122247555-122259792 bp, - strand Genetic Position: Chr6, 57.52 cM
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Alliance: |
Klrg1tm1.1(EGFP/icre)Flv page
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Germline Transmission: |
Earliest citation of germline transmission:
J:272661
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Parent Cell Line: |
JM8A1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Allele Type: |
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Targeted (Recombinase, Reporter) |
Mutation: |
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Insertion
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Klrg1tm1.1(EGFP/icre)Flv expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: The targeting construct containing a Frt-flanked Neomycin resistance gene (Neo), a thymidine kinase, and a fragment encoding an IRES-eGFP-iCre fusion protein was used for homologous recombination in ES cells to insert the reporter cassette immediately after the stop codon of the Klrg1 gene. Germline transmitted mice were bred with FLPo mice to remove the neo gene.
(J:272661)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Klrg1
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Klrg1 Mutation: |
22 strains or lines available
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Original: |
J:272661 Herndler-Brandstetter D, et al., KLRG1(+) Effector CD8(+) T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. Immunity. 2018 Apr 17;48(4):716-729.e8 |
All: |
2 reference(s) |
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