Mapt^tm1.1Bird
Targeted Allele Detail

Summary

• Symbol: Mapt^tm1.1Bird
• Name: microtubule-associated protein tau; targeted mutation 1.1, Adrian Bird
• MGI ID: MGI:6357824
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^tm1.1Bird page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272570
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct introduced upstream of exon 2 a loxP site, wild-type cDNA, SV40 polyadenylation sequence, loxP site and selection cassette. Cre-mediated recombination removed the inserted expressed sequence but left the selection cassette intact disrupting the endogenous gene open reading frame. (J:272570)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 453 strains or lines available

References

• Original: J:272570 Koerner MV, et al., Toxicity of overexpressed MeCP2 is independent of HDAC3 activity. Genes Dev. 2018 Dec 1;32(23-24):1514-1524
• All: 1 reference(s)